Tuesday, 13:15 - 13:40 h, Room: H 2033

 

Johannes Köster
Protein hypernetworks

Coauthors: Sven Rahmann, Eli Zamir

 

Abstract:
Protein interactions are fundamental building blocks of biochemical reaction systems underlying cellular functions.
The complexity and functionality of such systems emerge not only from the protein interactions themselves but mainly from the dependencies between these interactions, e.g., due to allosteric regulation or steric hindrance.
Therefore, a comprehensive approach for integrating and using
information about such dependencies is required.
We present an approach for endowing protein networks with interaction dependencies using propositional logic, thereby obtaining protein hypernetworks.
As can be expected, this framework straightforwardly improves the prediction of protein complexes.
We found that modeling protein perturbations in hypernetworks, rather
than in networks, allows to better infer also the functional necessity
and synthetic lethality of proteins in yeast.

 

Talk 1 of the invited session Tue.2.H 2033
"Bioinformatics and combinatorial optimization II" [...]
Cluster 12
"Life sciences & healthcare" [...]

 

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