Friday, 11:30 - 11:55 h, Room: MA 376

 

Alexandra Herzog
Discrimination of competetive model candidates for reversals in bacterium Myxococcus xanthus

Coauthors: Regina Gente, Ekaterina Kostina

 

Abstract:
Reversals in the gram-negative bacterium M. xanthus are still poorly understood. In general the spatial relocalisation of motility proteins is assumed to determine the dynamic orientation of the cell polarity axis and hence cell reversals. The difficulty is that experimental data from fluorescence microscopy on the simultaneous localisation of the involved proteins is both rare and of a more qualitative nature. Protein dynamics are recorded individually. Correlated data is available as qualitative observations only. Simulations of the dynamics of all involved proteins are typically the only means to study the processes under investigation.
In this talk we discuss numerical optimization methods for discrimination between available deterministic and semi-stochastic models for protein localisation of the supposed predominant proteins MglA and MglB. Qualitative reconstruction of the observed characteristic dynamics and transport times for available proteins is used as discrimination criteria. The extremely sparse experimental data sets mark a special challenge of this application.
Current results and limitations of this approach are discussed.

 

Talk 3 of the contributed session Fri.1.MA 376
"Model discrimination and experimental design" [...]
Cluster 12
"Life sciences & healthcare" [...]

 

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